Case report Pulmonary alveolar proteinosis: a complete response to GM-CSF therapy
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چکیده
Pulmonary alveolar proteinosis is a rare condition traditionally requiring treatment with whole lung lavage. The case is presented of a young man who obtained complete remission following treatment with granulocyte-macrophage colony stimulating factor, a new treatment option. (Thorax 2001;56:664–665)
منابع مشابه
Pulmonary alveolar proteinosis: a complete response to GM-CSF therapy.
Pulmonary alveolar proteinosis is a rare condition traditionally requiring treatment with whole lung lavage. The case is presented of a young man who obtained complete remission following treatment with granulocyte-macrophage colony stimulating factor, a new treatment option.
متن کاملGranulocyte macrophage colony stimulating factor therapy for pulmonary alveolar proteinosis.
We report a case of 58 year old female diagnosed with Pulmonary Alveolar Proteinosis (PAP) with recurrence of PAP after 5 repeated whole lung lavage, responding to subcutaneous injections of Granulocyte Macrophage Colony Stimulating Factor therapy (GM-CSF). Thus indicating that GM-CSF therapy is a promising alternative in those requiring repeated whole lung lavage
متن کاملPulmonary alveolar proteinosis.
Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized by impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous material rich in surfactant protein and its component. Novel insights from an animal model aided the discovery of granulocyte macrophage colony stimulating factor (GM-CSF) antibodies as a pathogenetic mechanism in ...
متن کاملAerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis.
Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) auto-antibodies have been found in many patients with pulmonary alveolar proteinosis (PAP). The present study reports a retrospective case series of patients who used aerosolised GM-CSF in the treatment of idiopathic PAP. Between 1999 and 2003, 12 patients elected to receive aerosolised GM-CSF (250 microg b.i.d. every other wee...
متن کاملState of the Art
Description of a “New” Disease Nature of the Accumulated Alveolar Material Published Features of Patients with PAP Presentation Demographic Features Smoking Age Arterial Oxygen Pressure Serum LDH Spirometric and Radiographic Features Diagnostic Procedures Histopathology Pathogenesis and Classification Acquired PAP Congenital PAP Secondary PAP Development of Effective Treatment Application and E...
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تاریخ انتشار 2001